Tubulin inhibitor 32

Research use only, not for human use.

Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.

Tubulin inhibitor 32 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 32 shows anti-proliferative activity and inhibits microtubule polymerization. Tubulin inhibitor 32 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin inhibitor 32 shows anti-tumor activity.

Cell Proliferation Assay Cell Line:HepG2, SW480, Hela, MDA-MB-231 cells Concentration:0-64 μM Incubation Time:48 h Result:Showed anti-proliferative activity with IC50s of 1.54, 37.53,24.61, 11.41 μM for HepG2, SW480, Hela, MDA-MB-231 cells, respectively.Cell Cycle Analysis Cell Line:HCT-116 cells Concentration:0, 0.5, 1, 2 μM Incubation Time:48 h Result:Caused cell cycle arrest in G2/M phase in a dose-dependent manner. Apoptosis Analysis Cell Line:HCT-116 cells Concentration:0, 0.125, 0.5, 2 μM Incubation Time:24 h Result:Induced cell apoptosis in a dose dependent manner.

Animal Model:4-6 weeks old male nude mice (HCT-116 tumor model)Dosage:50, 100 mg/kg Administration:P.o.; daily for 20 days Result:Decreased the tumor volume and tumor weight by 44.1% and 27.0% at the dose of 50 mg/kg, respectively

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Apoptosis

Apoptosis

Apoptosis

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2923531-39-7

325.36

C18H19N3O3

>98% (HPLC)

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N1=CC=C(C=2C=C(OC)C(OC)=C(OC)C2)N1C3=CC=C(N)C=C3

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(-20℃)

With Ice Pack

≥ 2 years