Tubulin inhibitor 32

CAS No. 2923531-39-7

Tubulin inhibitor 32( —— )

Catalog No. M37209 CAS No. 2923531-39-7

Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 445 Get Quote
5MG 686 Get Quote
10MG 938 Get Quote
25MG 1398 Get Quote
50MG 1822 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Tubulin inhibitor 32
  • Note
    Research use only, not for human use.
  • Brief Description
    Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.
  • Description
    Tubulin inhibitor 32 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 32 shows anti-proliferative activity and inhibits microtubule polymerization. Tubulin inhibitor 32 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin inhibitor 32 shows anti-tumor activity.
  • In Vitro
    Cell Proliferation Assay Cell Line:HepG2, SW480, Hela, MDA-MB-231 cells Concentration:0-64 μM Incubation Time:48 h Result:Showed anti-proliferative activity with IC50s of 1.54, 37.53,24.61, 11.41 μM for HepG2, SW480, Hela, MDA-MB-231 cells, respectively.Cell Cycle Analysis Cell Line:HCT-116 cells Concentration:0, 0.5, 1, 2 μM Incubation Time:48 h Result:Caused cell cycle arrest in G2/M phase in a dose-dependent manner. Apoptosis Analysis Cell Line:HCT-116 cells Concentration:0, 0.125, 0.5, 2 μM Incubation Time:24 h Result:Induced cell apoptosis in a dose dependent manner.
  • In Vivo
    Animal Model:4-6 weeks old male nude mice (HCT-116 tumor model)Dosage:50, 100 mg/kg Administration:P.o.; daily for 20 days Result:Decreased the tumor volume and tumor weight by 44.1% and 27.0% at the dose of 50 mg/kg, respectively
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2923531-39-7
  • Formula Weight
    325.36
  • Molecular Formula
    C18H19N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N1=CC=C(C=2C=C(OC)C(OC)=C(OC)C2)N1C3=CC=C(N)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li G, et al. Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities. Eur J Med Chem. 2023 Apr 5;252:115284. ?
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