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Tubulin inhibitor 32
CAS No. 2923531-39-7
Tubulin inhibitor 32( —— )
Catalog No. M37209 CAS No. 2923531-39-7
Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 445 | Get Quote |
|
| 5MG | 686 | Get Quote |
|
| 10MG | 938 | Get Quote |
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| 25MG | 1398 | Get Quote |
|
| 50MG | 1822 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTubulin inhibitor 32
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NoteResearch use only, not for human use.
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Brief DescriptionTubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.
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DescriptionTubulin inhibitor 32 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 32 shows anti-proliferative activity and inhibits microtubule polymerization. Tubulin inhibitor 32 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin inhibitor 32 shows anti-tumor activity.
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In VitroCell Proliferation Assay Cell Line:HepG2, SW480, Hela, MDA-MB-231 cells Concentration:0-64 μM Incubation Time:48 h Result:Showed anti-proliferative activity with IC50s of 1.54, 37.53,24.61, 11.41 μM for HepG2, SW480, Hela, MDA-MB-231 cells, respectively.Cell Cycle Analysis Cell Line:HCT-116 cells Concentration:0, 0.5, 1, 2 μM Incubation Time:48 h Result:Caused cell cycle arrest in G2/M phase in a dose-dependent manner. Apoptosis Analysis Cell Line:HCT-116 cells Concentration:0, 0.125, 0.5, 2 μM Incubation Time:24 h Result:Induced cell apoptosis in a dose dependent manner.
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In VivoAnimal Model:4-6 weeks old male nude mice (HCT-116 tumor model)Dosage:50, 100 mg/kg Administration:P.o.; daily for 20 days Result:Decreased the tumor volume and tumor weight by 44.1% and 27.0% at the dose of 50 mg/kg, respectively
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2923531-39-7
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Formula Weight325.36
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Molecular FormulaC18H19N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESN1=CC=C(C=2C=C(OC)C(OC)=C(OC)C2)N1C3=CC=C(N)C=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li G, et al. Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities. Eur J Med Chem. 2023 Apr 5;252:115284. ?
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